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However, despite the favourable effects on CVD factors, the trial did not demonstrate a significant reduction in cardiovascular outcomes

Tirzepatide FDA-approved as Mounjaro for type 2 diabetes (2022) and Zepbound for obesity (2023)

10.1021/acschembio.9b00939 257 YinJ.LinY.FangW.ZhangX.WeiJ.HuG.et al (2022)

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Introduction The glucagon-like peptide-1 receptor (GLP-1R), expressed in pancreatic beta cells amongst other tissues including brain, lung, stomach, and heart, is activated by the incretin peptide hormone GLP-1, secreted from enteroendocrine L-cells after food intake (1), to regulate postprandial glucose levels via the potentiation of glucose-dependent insulin secretion (24)